Keanu Reeves has quite a talent for making hearts flutter with his most affable personality, formidable action sequences, and fantastic acting. From getting his breakthrough with Bill & Ted franchise, he gained major stardom by portraying the role of Neo in The Matrix franchise. He continued to impress the audience in the action genre with the John Wick series.
Keanu ReevesCanadian actor, Keanu Reeves

Keanu Reeves Throws Light on The Matrix‘s Neo Vs John Wick Match!

Keanu ReevesKeanu Reeves as Neo in The Matrix

As the question looks quite intriguing to us, the actor insisted,
“Aw man, well, number one, they wouldn’t fight.”
The host then created a scenario to spar the two talented characters stating that Neo accidentally ends up killing the legendary hitman’s dog. He mentioned,
“I’m driving and the dog runs out in the street and I kill him… and then I can bring the dog back and John Wick’s like, ‘What’s going on?’” 
In his response, he further insisted,

“No! No. They wouldn’t fight. But maybe John Wick would try to help Thomas Anderson out in the real world, maybe against the machines.”
It’s quite clear that both the protagonists would avoid unnecessary fights with each other which is why he continued to remain adamant that they would not fight.

What’s Keanu Reeves’s Future in The Matrix and John Wick Franchise?

Keanu Reeves as John WickKeanu Reeves as John Wick

On the other hand, Reeves reprised his role in the fourth part of the sci-fi action series titled, The Matrix Resurrections. The film was unable to perform well at the box office with many panning its writing and weak action choreography. Given that there are no plans as of now regarding the fifth sequel, the Constantine actor has hinted in several interviews that he is willing to reprise his Neo role provided the story is good enough to make sense.